Hi Daniel, from my view we never saw enough traction from ESRI on this. But I did just complete my second deployment of a full NUTANIX environment for my Server environment and am happy to talk about it. We did not go with the Desktop Virtualization route, we are purely on the converged Server/Storage path.
Running VMWare/VSphere and Windows 2016/2019 VMs.
Thank you for your response. Did you deploy the datastores using AFS as 'OS' less file shares? Nutanix on the surface seems like a good fit for a highly available disk area and would be maintenance free if you go with Acropolis instead of using a Windows OS.
Sadly no, because of Auditing and Access-Control requirements we have to go with OS hosted shares for most items. Proper mapping of machines and distribution across your nodes helps a lot with reducing risk of contention and the needs to potentially have machines switch nodes. I went from a 3-node cluster to a 5-node, with one dedicated for cluster-class work.
The mixture of SSD and HDD has been a great performance boost; and maxing out your nodes with the most RAM you can is a huge boost for DB machines.