I had the same issue, I talked to the ESRI tech support and they found it is a bug and logged a bug #NIM089370
and they claimed that there is no work around, but I found one
the bug was if you have more than one columns in the interface(we had two) the information window take the width of the first column
and no matter what, it won�??t change until you change the width of the first column, but if I put the map and info windows in a completely
different grid inside the main grid with just only one column in it and specify the column number of the grid where it will be located,
it works just fine.