I am a new learning user and found that my mapping requirements forced me out of 10.3 up to Pro. Just playing around and learning, I have used as much as 30 gigs of chip memory on my 32 Gig Alienware 17r3. The 980m graphics card gets a real workout with 3D imaging and getting 8 gigs of memory on the card was a great idea. I have been impressed at how well 64 bit GIS Pro handles lots of memory, multiple cores and a fast graphics card. I have pushed my machine pretty much to its limits with GIS Pro and it performed really well. My recommendation is the usual if you are going to jump to GIS Pro, fast graphics card, fast CPU and lots and lots of memory. I don't regret basically maxing out my Alienware 17 at all. At the same time, ArcMap 10.4.1 never taxed the multiple cores, never used all the memory, never hit the graphics card hard and would crash a lot with memory faults. Put the same project in ArcGIS Pro and it just runs away with it and redraws are very impressive.
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