Here is my list of things to try when having a random ArcGIS problem:
- Restart ArcGIS
- Restart computer
- If problem seems map-related:
- Delete Normal.mxt, found in install folder. For me: C:\Users\{USERNAME}\AppData\Roaming\ESRI\Desktop10.2\ArcMap\Templates
- Copy mxd to new map document
- If problem seems data-related
- Rebuild spatial index.
- If shapefile, save to GDB feature class. If GDB feature class, save to shapefile.