@DavidPike is correct if you switch to "using tiles from cache" and the tiling scheme box remains empty. Either the cache structure in the D:\ location has been modified and the map service can no longer find the conf.xml in that path (<cache directory>\<service directory>\ImageryMOXBase\conf.xml or since this is deployed to the root of ArcGIS Server, <cache directory>\ImageryMOXBase\conf.xml); or there is in fact no cache in the D:\ cache directory. To change the cache directory, you need to first stop the service. You can also check the available / configured cache directories for this ArcGIS Server Site If you want to dig deeper, you can also use the Admin web page to look at service configuration properties https://<myserver>/<server wa name>/admin/ navigate to the service, and find the properties section, and look for cacheDir and isCached property values
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