In ArcGIS for desktop we can deselect features from particular layers in the event that we inadvertently select features from multiple layers - it would be nice to see that functionality return in ArcPRO.
Good news - this is available in ArcGIS Pro, in two locations.
 The layer's context menu: right-click layer in TOC, expand 'Selection', click 'Clear Selection'
 On the Feature Layer > Data ribbon tab: select the layer in the TOC, on the ribbon click on the Data sub-tab for the Feature Layer context group, and click the Clear button
Hope this helps you with your workflows!
Thank you for the reply. While your method does allow for the clearing of selected features on a layer by layer basis, why not keep the existing functionality from ArcGIS Desktop? It is nit picky but I do feel that the change is a step backwards in efficiency.
ArcGIS Desktop allows for easy deselecting from a single tab while you need to go into a context menu for each layer you want to deselect in ArcGIS Pro. Implementing the desktop selection/deselection would be a nice quality of life improvement.
Aha, I see - you're after the full panel-like control, that supports feature selection management and layer selectability.
I'll check with the team responsible for that section of the software and let you know.
Related question: https://community.esri.com/message/845867-re-list-by-selection-no-selected-features-are-displayed?commentID=845867&et=watches.email.thread
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