Use this thread to discuss best practices regarding architecting and deploying ArcGIS as an enterprise Web GIS.
For the latest Best Practices, refer to Architecting the ArcGIS Platform: Best Practices

Thanks,
ArcGIS Telecom Team

This blog may help those who are administering a portal. /blogs/spatialninja/2018/11/17/administering-your-portal-2018-tips-tricks
FYI, this Esri whitepaper might be a good reference,

Hope this helps,
Patrick Huls, that intial link you posted last year "Architecting the ArcGIS Platform: Best Practices" now 404's... That is probably not "best practice"
, so I guess you would like to correct that
.
Thanks! Link updated.
https://assets.esri.com/content/dam/esrisites/media/pdf/architecting-the-arcgis-platform.pdf