arcpy.MakeFeatureLayer(fc, "lyr", "MY_FIELD in ('A','B')": if int(arcpy.GetCount_management("fl").getOutput(0)) > 0: arcpy.CalculateField_managment("fl", "MY_FIELD", "None", "PYTHON")or
arcpy.MakeFeatureLayer(fc, "lyr", "MY_FIELD in ('A','B')": if int(arcpy.GetCount_management("fl").getOutput(0)) > 0: arcpy.CalculateField_managment("fl", "MY_FIELD", "NULL", "VB")