Hi Adam,
All my settings seem to be OK, I have other 1.X flex projects running with no issue. I imported the 2.2 flex project from ESRI into the Flex Builder, the auto build is on and the project properties seem to be OK. There is no index.html in the src folder, which I believe is part of the problem.
My goal is to migrate my ESRI 1.X flex projects to ESRI 2.X
Chris