Help Opening ArcGIS Pro 3.1.4

[DanielKhuat]

Our users started having trouble opening some large aprx  files on ArcGIS Pro last week, and those files opened normally earlier in the month with no major changes. Some large aprx files for a project can open, but we're having a growing number of files across different projects that cannot open. Most of the time, these files would stay at the loading screen without opening even after a few hours (see attached image).

We've been troubleshooting for the past week and tried the following:

• Rebooting our virtual servers (Citrix) where our GIS files are located
• Updated latest patches for ArcGIS Pro 3.1.4 (what we're currently using with our Enterprise license)
• Clear/refresh caches

Despite our efforts, we're still having difficulty opening these files. However, we were able to open one of those aprx files by copying the entire project folder onto a different network drive, and then opening it on ArcGIS Pro 3.6 (the latest version) on our physical desktops. 

[Robert_LeClair]

Definitely sounds like a network issue somewhere as you mentioned a local copy opened as expected on the C: drive.  Question - do you have OneDrive running as well?  In a similar support case, the customer and the analyst went through many ideas such as disabling indexing, checking to see if the Windows Task Scheduler was running some ArcGIS Pro indexing (it was in this case even though it was disabled in the app).  Anyway, they disabled the OneDrive on Citrix for testing purposes and latency dropped.  Final resolution was:  The default user folder on the machine was configured for OneDrive. In ArcGIS Pro, default locations in the Options were set to OneDrive user folder. After removing and deactivating OneDrive on the VM, the latencies were resolved