For cases when ArcGIS Pro is thinking due to a slow process:
If I click elsewhere in the application while it’s thinking, there will of course be a lag. But when it does finish thinking, it should honour that next position I clicked, not apply the click to the last thing that was selected, such as a selected layer in the table of contents.
I believe other applications and operating systems behave in a more intuitive way: when lagging, the current mouse position is honoured.
More information in this post — about layer properties changes being slow, and what happens when I click elsewhere: https://community.esri.com/t5/forums/postpage/board-id/arcgis-pro-ideas
ArcGIS Pro 3.0.2