ArcGIS Pro 3.4.3; Oracle 19c 11.3 EGDB:
Attribute Table > right-click a field header > Custom Sort
The user sets up a custom sort and clicks OK. When they re-open the Custom Sort dialog, the previous sorting is preserved, but the OK button is greyed out.

It seems somewhat unintuitive that the OK button is greyed out, even though the sorting setup is valid. I figure it's greyed out because no change has been made to the sorting, so there's nothing new to commit. If the user makes a change, the OK button will become clickable again.
With that said, greying out that button seems unnecessary. If a user wants to open the dialog and click OK, I say let them do it. That would be more consistent with other parts of Pro such as Properties dialogs like Map Properties.