Hi Brian,
You can create as many TCP inputs as you like (within reason, I'm sure), and run a simulator instance to push to each one. Regarding which ports to use, you can specify those. I typically stay around the neighborhood of the default, i.e. 5566, 5567, 5570, etc. A TCP input's port is specified in the Advanced properties, as seen below, where I created a new TCP input with port 5566 (click image to enlarge):
[ATTACH=CONFIG]32871[/ATTACH]
and then specify that port in your Simulator, as seen below:
[ATTACH=CONFIG]32872[/ATTACH]
Hope this helps.
Mark