There is a certain area (3 miles S.E. of McKittrick, CA on Reserve Rd) that goes gray at a certain zoom level (13). If I zoom in or out until the level changes to 12 or 14, the portion of the map is then drawn. The gray rectangle (is this a tile?) is only a portion of the map that is otherwise OK at every level that I have looked at. I scrolled around a bit, too, and didn't see this anomaly at another location, although scrolling around is tedious at this zoom level and with as many graphics as I am handling.
My app initially has 21 layers and a total of almost 2600 graphics, which someone has indicated might have something to do with the problem (however, the app at times has over 260 layers and over 35,000 graphics and although it is not "snappy", it still functions). It happens in two different pages in my app (same map reference but different ESRI.Map object), but does not happen in a simple sample app with just a few layers and graphics, using the same Map.
I typically load the map once as the first Layer and keep it, but I have also forced it to reload; the problem remains. Finally, this is not random. It is repeatable every time.