It would be great if it was possible to utilize multiple replace functions in one Arcade expression in ArcGIS Online. Currently, only the last replace function is actually honored and the others are ignored. See example below:
Replace($feature["Gate_Number"], '51 east entrance', 'East Entrance')
Replace($feature["Gate_Number"], '54 middle entrance', 'Middle Entrance')
Replace($feature["Gate_Number"], '1', 'West Entrance')