Hi @HanhNguyen2 ,
You may have be confused between the raster and mosaic dataset types.
Raster Datasets refer to image formats supported by ArcGIS Pro (most often in TIF/GeoTIFF).
A Mosaic Dataset is an image management object. It allows you to display a dataset from your catalog of raster datasets.
I would highly recommend going through each of the Image Management documentation as storing and displaying 2TB of imagery aerial data has its complexities and will require a depth of planning to meet your requirements. I would also read through Imagery Workflows which will guide you through most all of the image management planning and processes.
In short, the answer is store it as a raster, and have it added into a mosaic dataset. How you configure mosaic dataset to serve your rasters is up to the requirements of your use and users.