PRO simplifies things at least in terms of upgrades (2.0 -> 2.1, 2.1 -> 2.2, etc.) because it will prompt users in the same way you'd get java or adobe prompts regarding updates available. I can't say I have specifically looked at patching sequences for Pro yet because we currently have 5-10% of our GIS usage occurring in PRO, all by power users, so our real enterprise focus is still around desktop. I'm hopeful though that like Server there is a more streamlined workflow for identifying/installing patches to PRO and guess we will find out once we make that cutover.