ArcGIS Server: Can temporary files be deleted from arcgis Local AppData folder?

[FrancescoTonini2]

I have an ArcGIS Server 10.4.1 deployed on an AWS EC2 instance with Windows Server 2012 R2 on it.

I noticed the C:/ drive attached to the instance is quickly running out of space and I was able to identify the source of it. Under C:/Users/arcgis/AppData/Local/Temp I have several big files that were generated at different points in time.

My question is: can I safely remove these files manually to clean up space without compromising the functionality of several web services published and hosted on that same machine?

[stevecater1]

We have 132 GB of .sde, .gdb folders, tmp-ags-export-* folders in the C:\Users\serviceaccount\AppData\Local\Temp   location.  Portal, AGS and Datastore single deployment 10.9.1. So obviously in this case nothing is being deleted by the application. Esri Case #03731334