Hi I am building our new server and I am wondering if there is any benefit to storing the arcgiscache, arcgisjobs, arcgisinput and arcgissystem locations on another drive on my server? If it matters, I am using a virtual server running Server 2012 R2 and using Server 10.2.2. Thanks!
From my experiences with IT, it is easier to expand an additional drive such as an E-drive than it is to expand the C-drive to account for more storage that is needed as you create more cached mapservices.
I don't know if there is an actual advantage performance wise, but to add to what Michael mentioned, IT also tend to lock down the c-drive, for security reasons. So putting those folders on the d-drive or other "local" drive makes it easier to manage, and I have not found any negative performance. There are still some AGS folders that remain on the c drive.