Is there a way to label features from one map frame differently from features in other map frames?

AdamG2

I'm creating a map layout that shows points on a map, but there are certain regions of the map that have clusters of features making it impractical to label all features at small scale. I want to include additional map frames at a larger scale to allow for clearer viewing of the clustered features. 

I'd like to have a layout where feature labels in the large scale map frames are not repeated in the smaller scale map frame.