license manager registry keys caution re: permissions

MattWilkie1

In FAQ: Does the ArcGIS Administrator allow switching of the License Manager or the software seat type? there's the caution:

In a network environment it is not recommended to give Domain Users or Authenticated Users permissions to these registry keys. If this is done, computer functionality will slow to a crawl. It is recommended to give full control permissions to the local users group in order to authenticate everything locally, rather than across the domain.

Can anyone unpack the full meaning of this for me? For instance:

• Does "Domain Users" mean the specific Active Directory object container called "Domain Users" or any account that happens to be member of Domain Users? (probably the container, but let's be thorough and precise)