Using ArcMap 10.3.1 - I applied linear referencing to a big tangled looping around on itself many times mass of separate polylines (I didn't combine any of them, all had a unique identifier) I used the two fields option as the measure source with a FROM and TO attribute field. What I haven't been able to figure out is how the program determined which end of the polyline to use as the starting point (the FROM field) and which to use as the end point (the TO field). How does Arc determine this?