I'm running Portal for ArcGIS 10.6.1 and trying to use an Arcade Attribute Expression to populate a pop-up. Here is my syntax:
<SPAN class="string token">"The setback for the "</SPAN> <SPAN class="operator token">+</SPAN> <SPAN class="token function">Proper</SPAN><SPAN class="punctuation token">(</SPAN>$feature<SPAN class="punctuation token">.</SPAN>FUNCTCLASS<SPAN class="punctuation token">)</SPAN> <SPAN class="operator token">+</SPAN> <SPAN class="string token">" road class is "</SPAN> <SPAN class="operator token">+</SPAN>
<SPAN class="token function">Decode</SPAN><SPAN class="punctuation token">(</SPAN>$feature<SPAN class="punctuation token">.</SPAN>FUNCTCLASS<SPAN class="punctuation token">,</SPAN>
<SPAN class="string token">"FREEWAY"</SPAN><SPAN class="punctuation token">,</SPAN><SPAN class="string token">"150 feet "</SPAN><SPAN class="punctuation token">,</SPAN>
<SPAN class="string token">"PRINCIPAL ARTERIAL"</SPAN><SPAN class="punctuation token">,</SPAN><SPAN class="string token">"150 feet "</SPAN><SPAN class="punctuation token">,</SPAN>
<SPAN class="string token">"MINOR ARTERIAL"</SPAN><SPAN class="punctuation token">,</SPAN><SPAN class="string token">"100 feet "</SPAN><SPAN class="punctuation token">,</SPAN>
<SPAN class="string token">"MAJOR COLLECTOR"</SPAN><SPAN class="punctuation token">,</SPAN><SPAN class="string token">"100 feet "</SPAN><SPAN class="punctuation token">,</SPAN>
<SPAN class="string token">"MINOR COLLECTOR"</SPAN><SPAN class="punctuation token">,</SPAN><SPAN class="string token">"75 feet "</SPAN><SPAN class="punctuation token">,</SPAN>
<SPAN class="string token">"STREET"</SPAN><SPAN class="punctuation token">,</SPAN><SPAN class="string token">"50 feet "</SPAN><SPAN class="punctuation token">,</SPAN>
unknown<SPAN class="punctuation token">)</SPAN>
<SPAN class="operator token">+</SPAN> <SPAN class="string token">"and the road frontage is "</SPAN> <SPAN class="operator token">+</SPAN>
<SPAN class="token function">Decode</SPAN><SPAN class="punctuation token">(</SPAN>$feature<SPAN class="punctuation token">.</SPAN>FUNCTCLASS<SPAN class="punctuation token">,</SPAN>
<SPAN class="string token">"FREEWAY"</SPAN><SPAN class="punctuation token">,</SPAN><SPAN class="string token">"1320 feet."</SPAN><SPAN class="punctuation token">,</SPAN>
<SPAN class="string token">"PRINCIPAL ARTERIAL"</SPAN><SPAN class="punctuation token">,</SPAN><SPAN class="string token">"1320 feet."</SPAN><SPAN class="punctuation token">,</SPAN>
<SPAN class="string token">"MINOR ARTERIAL"</SPAN><SPAN class="punctuation token">,</SPAN><SPAN class="string token">"500 to 660 feet."</SPAN><SPAN class="punctuation token">,</SPAN>
<SPAN class="string token">"MAJOR COLLECTOR"</SPAN><SPAN class="punctuation token">,</SPAN><SPAN class="string token">"500 to 660 feet."</SPAN><SPAN class="punctuation token">,</SPAN>
<SPAN class="string token">"MINOR COLLECTOR"</SPAN><SPAN class="punctuation token">,</SPAN><SPAN class="string token">"330 feet."</SPAN><SPAN class="punctuation token">,</SPAN>
<SPAN class="string token">"STREET"</SPAN><SPAN class="punctuation token">,</SPAN><SPAN class="string token">"250 feet."</SPAN><SPAN class="punctuation token">,</SPAN>
unknown<SPAN class="punctuation token">)</SPAN><SPAN class="line-numbers-rows"><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN><SPAN></SPAN></SPAN>
The syntax checks out when I test it:

But I cannot get it to show up in the actual pop-up. I've tried using Display by "A description from one field" and selecting the expression from the drop-down list; I've also tried "A custom attribute display" with a reference to the expression. Either way, the sentence shown in the Value portion of the test above does not appear in the pop-up. When I go back into the pop-up settings, the options have reset to "A description from one field" and my expression is still saved in the Attribute Expressions section.
I thought this might be a 10.6.1 bug and I did find and install patch ArcGIS-1061-PFA-SEC2019U1-Patch, but that didn't fix the issue. I also tried to put the same expression into ArcGIS Online, but I got the same result.
Maybe Decode isn't supported for pop-ups in 10.6.1? I checked the version matrix, but I'm not certain that I'm reading the chart right.