This might be off topic of this forum. Here are some high level steps.1. create a http handler with asp.net responding to a URL. take a look at system.web.IhttpHandler interface in the asp.net lib.2. use esri.request to send the query to the http handler, which returns a response with the results.3. handle the result on client once the results are back.
Yes, you can use the JS API with any server side platform.
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