There are known issues with NoData values with ISDEF Image Services. In order to accommodate the NoData, I would recommend creating Mosaic Datasets that can handle the NoData better and allow the statistics to be generated correctly if you are using ArcGIS 10. At ArcGIS 10, the footprints can be rebuilt properly and the statistics generated will be correct. If you are using a prior version, then manual editing of the isdef is required. For more information about how to edit it properly, log a Support Incident.
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