I have a primary Arc Pro project which contains all of my main content that I use on a daily basis. Ever since upgrading to 2.2, Pro crashes whenever I open that project on startup of Pro, with the error message that ArcGIS Pro encountered a serious issue and could not continue and the option to send an error report.
If I open a different project, however, and from there open the problem project, it is fine. I have been unable to identify what the issue is with that project file or contents.