We're in code red trying to figure out why the Legend widget, LayerList widget and the Editor widget are not working properly in Edge all of a sudden. 4.28, no recent code changes.
The operation symptoms in Edge: widgets (above) can no longer interact with the map, attempting to get a map popup seizes the app (Other interactions with the mapview cause it to seize as well), Calcite widgets we've built no longer interact with the mapview, others.
<edit>This also affects labelling in certain maps - apparently authored in ArcGIS Pro. But it is related, which is really bizarre.</edit>