Hi Bruno - Yes, we have found issues with 16.5 (the resolve text conflicts will cause the workspace to crash during a map publish) and the MPS doesn't route correctly (we have to go back to 16 for that one). Unfortunately we made a lot of cartographic changes in 16.5 prior to realizing how problematic it would be.
Do you point your workspace warehouse to shapefiles or a file gdb? We use shapefiles, but it seems like a file gdb might be faster while I'm working with geomedia. We need a successful maproll before I'm willing to try it though.