See the functions below:Public Const Guid_SpatialAnalyst As String = "{3C5059FE-9F15-401A-94ED-EED914D73E3E}"        Public Shared Function IsSpatialAnalystAvailable(ByVal application As IApplication) As Boolean
            Dim uid As New UID
            uid.Value = Guid_SpatialAnalyst
            Dim extension As IExtension = application.FindExtensionByCLSID(uid)
            Dim extensionConfig As IExtensionConfig = DirectCast(extension, IExtensionConfig)
            Return (extensionConfig.State <> esriExtensionState.esriESUnavailable)
        End Function
        Public Shared Function IsSpatialAnalystEnabled(ByVal application As IApplication) As Boolean
            Dim uid As New UID
            uid.Value = Guid_SpatialAnalyst
            Dim extension As IExtension = application.FindExtensionByCLSID(uid)
            Dim extensionConfig As IExtensionConfig = DirectCast(extension, IExtensionConfig)
            Return (extensionConfig.State = esriExtensionState.esriESEnabled)
        End Function
        Public Shared Function EnableSpatialAnalyst(ByVal application As IApplication) As Boolean
            Dim uid As New UID
            uid.Value = Guid_SpatialAnalyst
            Dim extension As IExtension = application.FindExtensionByCLSID(uid)
            Dim extensionConfig As IExtensionConfig = DirectCast(extension, IExtensionConfig)
            If extensionConfig.State = esriExtensionState.esriESUnavailable Then Return False
            If extensionConfig.State = esriExtensionState.esriESEnabled Then Return True
            extensionConfig.State = esriExtensionState.esriESEnabled
            Return True
        End Function
        Public Shared Function DisableSpatialAnalyst(ByVal application As IApplication) As Boolean
            Dim uid As New UID
            uid.Value = Guid_SpatialAnalyst
            Dim extension As IExtension = application.FindExtensionByCLSID(uid)
            Dim extensionConfig As IExtensionConfig = DirectCast(extension, IExtensionConfig)
            If extensionConfig.State = esriExtensionState.esriESUnavailable Then Return False
            If extensionConfig.State = esriExtensionState.esriESDisabled Then Return True
            extensionConfig.State = esriExtensionState.esriESDisabled
            Return True
        End Function