Dan,
Thanks for the response. From what little information I can gather from their infrastructure, they seem to be very concerned with maintaining coherent geodata and workflow management. Since it looks as more of workflow management system then any actual geodata creation / manipulation, I didn't think it would have any issues or limitations.
I have not encountered any issues or limitations, but that's only because I haven't received any geodata from them (yet) that would be in any way associated with this extension. I just wanted to see if anyone within the community has used these two products together (Runtime Engine and Production Mapping extension) and ran into any issues themselves in order to get the most accurate information to answer my client's query.
Thanks so much for the help!