ArcGIS Pro 2.1 (Geoprocessing Broken)

[MichaelKnapp]

I'm hoping this is something simple. After updating ArcGIS Pro to 2.1, Geoprocessing Tools are not working. 

On opening a project, I get this message:

The path, however, does exist. 

I've uninstalled and reinstalled a few times (including ArcGIS Desktop) to no avail. 

Basic command line Python in Pro is working, but no toolboxes show up:

Any ideas?

Thanks!

m knapp

[MichaelKnapp]

Thanks for the useful list Todd... when I get it all worked out, I'll post what I find here.