This post is aimed at helping you decide when to use the new @arcgis/webpack-plugin or esri-loader in applications built with webpack. I've recently had the opportunity to put the new webpack plugin through it's paces, and I came away with the impression that Rene Rubalcava, Yann Cabon, and the team have taken an important step forward in making the ArcGIS API for JavaScript more interoperable with other JavaScript frameworks and build tools.
TLDR: Scroll down to see the Conclusion.
Rumors of esri-loader's demise have been greatly exaggerated
So you may be wondering why would you ever want to use esri-loader now that we have the plugin?