Hello.
This is my first GeoNet post.I hope it isn't too basic.
My organisation uses an third party application which uses ArcGIS Engine 10.4.1 as the core software for its mapping componnt. I currently use ArcGIS 10.2.2 for Desktop to prepare spatial datasets for use within this third party application. I don't know much about ArcGIS Engine, but I assume that it is a component of the ArcGIS for Desktop installation?.
A colleague of mine has recently upgraded to ArcGIS Desktop 10.6, which presumably includes ArcGIS Engine 10.6 as part of the install. My colleague can no longer prepare datasets for the third party application. I think that this is due to the lack of compatibility between the third party application and ArcGIS Engine 10.6.