When using a scaled display (natively, not the ArcGIS Pro setting), I experience issues with certain UI elements. It appears to be any "floating" element, such as context/drop-down menus (any right-clicks, hamburger buttons, expanded tool galleries in the ribbon, or the ribbon itself if auto-hide is on) and any floating windows (such as Calc Field, Select by Attributes).
When mousing over any of these elements, every part of it disappears other than what the cursor is hovering over. Sometimes I can still click the option I want and have it work, but if it is a longer menu, clicking only results in the thing that is underneath it being clicked. I've attached a couple of screenshots, but it's difficult to capture the behavior, so hopefully I've explained it well enough - and now that I'm trying it, the floating windows are fine in this setting, unlike through the remote connection, so I will have to add a screenshot of that from home, if necessary.
I thought this was a remote desktop connection graphics driver mismatch issue, but I just experienced this while in the office on the physical machine. I recently replaced my second office monitor so that they are now both the same model (see below). When displayed at 100%, I can fit so much more on screen, but it's more difficult to read as a result, so I scale it up to 125%. When I changed the setting to 125 is when this issue started happening on the office computer as well. Previously, I had only experienced it while remoting in if I tried using Pro on my laptop screen instead of the external second monitor I have set up (where it works fine).
Office displays: Dell P2415Q x2, extended, 59.997 Hz, 3840 x 2160, 8-bit, RGB, SDR
Display adapter: NVIDIA RTX A4000 (driver v.31.0.15.28886
ArcGIS Pro 3.1.4 (this was also happening on 2.9.5)
Windows 10 Enterprise