I have an ArcGIS Pro project that will only open as read-only. I don't have it open anywhere else and I've tried closing everything and even restarting my computer.
Before this happened, I was migrating .mxd documents to Pro projects and feature classes from .mdb databases to .gdb databases
don't know what ArcGISIndexingServer is, but by chance is there non-local data in the aprx? If so, try remove any layers that aren't locally stored incrementally with a save after each removal to see if you can narrow down the offending data
Matt - let's try to disable the ArcGISIndexingServer process and see if that resolves the locked/read-only *.aprx. To do this:
1). Close ArcGIS Pro.
2). Go to Start Menu> Search for "Task scheduler" > Open Task scheduler.
3). On the left hand pane in Task scheduler, Click on Task scheduler(Local) > Task scheduler library.
4). In the list scheduled tasks, locate the task with name like "ArcGIS Pro Indexing (Your_Username)" >Right click on the task> Disable the task.> Close Task Scheduler.
5). Reboot the machine
Once you reboot the machine, attempt to load the *.aprx in question. What is the result?
Okay - next thing. In ArcGIS Pro, go to Project-Options-Application-Indexing. Click "Don't create index" and uncheck "Update the index periodically" Then close ArcGIS Pro, redo the steps for Task Scheduler. What is the result?