or...
- set the processing extent around the pixels of interest
- and also set SnapRaster=your input raster
- RasterToPoint
- edit the attributes (of the points)
- PointToRaster and use the same cell size and extent as your original raster
- use IsNull and Con to "insert" the changed raster into your original raster
Note that RasterToPoint works with integer, floating point or string data.
-Steve