I've been really busy this year and only just now started looking at the 10.1 beta. I noticed that the current version of comtypes croaks when trying to wrap esriSystem.olb. Fortunately, you can remedy this by adding the following entry to the _ctype_to_vartype dictionary in automation.py:
POINTER(BSTR): VT_BYREF|VT_BSTR,
If there's a better approach I'd like to hear about it.
Also note that arcpy.da approaches ArcObjects via comtypes in terms of performance. To query and hydrate ~500,000 polygons from a file GDB feature class:
ArcGIS 10.0SP3:
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ArcObjects/comtypes: 31 sec
arcpy.SearchCursor: 96 sec
ArcGIS 10.1 Beta:
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ArcObjects/comtypes: 21 sec
arcpy.SearchCursor: 85 sec
arcpy.da.SearchCursor: 27 sec