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Why can't the breakpoint be ???hit??? when debugging an ArcGIS 10 Add-In?

Question asked by jakubsisak on Oct 25, 2011
Latest reply on Nov 3, 2016 by srbricker
Now and then I run into the following problem:
  I start debugging the Add-In and breakpoints are ignored. Almost  seems like the communication between the IDE and the component is not  working.
  My problem is that the last time this had happened I resolved it and now I can't remember what I did to fix it.

I also posted the a similar question here, but the solution there does not work.