This is a recent problem which has started occurring since moving to Win 10.
When using 3D analyst to draw a line ('Interpolate Line') to get a profile graph of a section of a DEM, ArcGIS crashes completely when attempting to draw the profile graph (regardless of length). I also notice that the other two options 'Point Profile' and 'Terrain Point Profile' are greyed out which was not the case in Win7
Lots of available space in Default.gdb location - even tried setting a different Default.gdb in case this was the problem.
Running Win10 Enterprise / Build 3.25 / 64GB RAM
ArcGIS Desktop 10.5.1(.7333) / Advanced