This question has been asked several times, without a satisfactory response regarding a solution, I am asking again, in the hope that *someone* has a solution: (other than reinstalling Windows)
I am running ArcGIS 10.5.1 on Windows 10. And have not had any problems for years except this one, which started 2 days ago; since then, I have repaired, uninstalled, reinstalled to no avail. ArcGIS runs happily for a while and when closed it is always questionable if it can be opened again without a problem; generally it WILL open, however, I can almost guarantee that if I power down the computer and restart it - ArcGIS will fail with this error message - see below: (several pop ups related to different DLLs, all of whose sizes appears to have shrunk to zero).
"C:\Program Files (x86)\ArcGIS\Desktop 10.5\bin\AppInitializerLib.dll is either not designed to run on Windows or it contains an error try reinstalling the program ... Error status: Oxc0000020"
The only change to the computer are the auto updates by windows, I have a suspicion that updates may be causing a problem? I am not sure. Weirdly this seem to happen (although I am not 100% sure) during the window of time that the computer is designated not to be active, and ergo, updates are possible. I have run a malware checker, virus checker and file system checker, all which tell me that the system is ok; the problem appears *only* affect ArcGIS so far...