Working in a water distribution company, I'm currently using a Web Application (Esri Web App Builder) in which I isolate a part of a water net from a leak or a main break thank to the "Isolation Trace" widget.
The geoprocessing works well except when I publish it from a SDE geodatabase. In this case, the Isolation Trace shows an error (joined in this message). I guess it is a problem of In_Memory parameters in the geoprocessing but not sure. I don't know if it can help you but my database Platform is SQL Server.
Let me know if you need more information to be able to help me.
Thank you in advance