Hello John,
Your question doe not explicitly state your goals. I see two possible answers here.
1) you are referring to the tiles of the aerial photography as supplied by and image vendor. Here in Australia for 10, 15 & 20 cm imagery we typically see the imagery delivered in 1km tiles. These are then typically delivered as a seamless mosaic that can be added to an ArcGIS Mosaic Daatset
2) the tiling scheme defined for delivering a cache in a wen service. In this istane I typically start with the ArcGIS Online tiling scheme but then I increase Scale of the tiles depending on the imagery. Generally speaking a 50cm image is cached to 1:512. The smallest scales that consumer mapping applications go to is 1:1128 which is roughly 1 m resolution. If I have higher resolution imagery then I cache further.
i Hope this helps answer some of your question
Gordon
