If I have a point layer in a webmap with a "Counts and Amounts (Size)" renderer, when clicking on an area not covered by a point on the map, and popups are enabled, I get "No Information Available" displayed. This does not happen if I change the renderer to "Counts and Amounts (color)" or Heatmap.
Here is a link to a web map which displays this problem.
http://directrelief.maps.arcgis.com/home/webmap/viewer.html?webmap=38c111eef67b4ae3b913301036562300
Screenshot of layer settings
No Information Available