If I have a point layer in a webmap with a "Counts and Amounts (Size)" renderer, when clicking on an area not covered by a point on the map, and popups are enabled, I get "No Information Available" displayed. This does not happen if I change the renderer to "Counts and Amounts (color)" or Heatmap.
Here is a link to a web map which displays this problem.
Screenshot of layer settings
No Information Available