We just recently stood up Imager Server 10, registered it with AGS, and have created and compiled our first image service. The Server reports that things are good...the Service Provide reports that things are good...but every time I try to publish our service I get the error "ISCDef does not exist", although I am able to clearly point Server to the file to in order to try to publish it. The SOC has access to the directory where these files are stored, and has been able to serve map services with no problems.
Just looking for ideas to try next...