I asked the question "Is it possible to exclude feature classes from replication that participate in a topology on the parent?"
After reading the web help I found that...
"All feature classes participating in a topology are replicated together. Individual topology feature classes cannot be excluded from a replica." See help topic.
In this case where editors have a geometric network or parcel fabric with over a million features in a production -> publication environment replication would produce significant overhead in the publication workspace due to unnecessary data being replicated.
A workflow providing for topology in the production environment and more flexibility for replicating only the desired feature classes and features based on a sql query would prove helpful.
