Hello,Just thought I'd let everyone know what I ended up doing. I used HKEY_LOCAL_MACHINE\SOFTWARE\ESRI\ArcGIS\RealVersion to determine the version. From this, you can parse out the version - 10.0 or 10.1. And then you can use this to access the appropriate registry key: HKEY_LOCAL_MACHINE\SOFTWARE\ESRI\Desktop10.x.Cheers,Anthony