Add-ins are not backward compatible. Add-ins targeting 10.1 will not work with 10.0 but would work with a subsequent release like 10.2 for example.When you compile an ESRI Add-in you are linking to ESRIs Primary Interop Assemblies (PIAs) that are not backwards compatible. If you need to support clients on 10.x you can compile everything against 10.0 or maintain a 10.0 and 10.1 dev system.