Raster calculator: excluding no data pixels

[EyalSaiet]

In ArcGIS Pro, is there a way in the Raster Calculator to exclude the no-data pixels that are defined in my raster as 65535? I see there is a mask option, is that my only option is to create a mask? 

Failing to do so converts the 65535 to a float number which then I cannot select as no data in symbology as you can see in the atached document.

[EyalSaiet]

Can anyone in ESRI respond to this question?

thanks

[KoryKramer]

Here I mocked up a raster where nodata values are 65535

Use Reclassify—Help | ArcGIS Desktop (either Spatial Analyst or 3D Analyst) to reclassify those cells to NoData:

Does that work for you?