I have a project where the project folder is taking up 100GB of storage on my PC, which is causing problems with my available storage. Is it possible to move the project folder to an external drive without losing all the work on the project so far?
Your paths to your data will all be affected.
Perhaps you should clear out your caches and history first and perhaps create a project package on the external physical drive as well
Share a project package—ArcGIS Pro | Documentation