The current animation tool (version 2.7) regenerates the keyframe thumbnails every time you re-open a project (and select a target map/scene with animation configured).
If the content of your map or scene is 'heavy' - eg, large LAS point clouds, then this can significantly affect the performance of Pro for no real benefit (eg, 15 minutes of high CPU/GPUy usage just creating the thumbnails).
It would be good if you could either toggle keyframe thumbnail creation on and off, and/or if it could save the thumbnails once created, so that it doesn't have to recreate them.
Cheers,
Ross